A key objective of SSVN is to increase participation in research. The initial stages of this objective was to provide a central resource for all currently active vasculitis research studies.
More information on active vasculitis research studies is available below including contact details and recruiting Health Boards. Please click on each study and further information will appear.
Active research
COMBIVAS
Mechanistic study to assess whether dual B-cell immunotherapy by co-administration of rituximab and belimumab will result in improvements in biological endpoints, functional outcomes and clinical status compared to rituximab with placebo
Recruiting health board(s): GGC
PI: Neil Basu
Web page: https://cctu.org.uk/portfolio/vasculitis/trials-open-to-recruitment/combivas
Contact details: neil.basu@glasgow.ac.uk
BIOVAS
A pragmatic, randomised, double-blind, placebo-controlled, modified-crossover trial of biologic therapy for refractory primary non-ANCA associated vasculitis in adults and children
Recruiting health board(s): GGC
PI Neil Basu
Web page: https://www.fundingawards.nihr.ac.uk/award/17/83/01
BIOVAS Trial Inclusion/ Exclusion criteria
Contact details : neil.basu@glasgow.ac.uk
Evaluating the health burden of systemic vasculitis
National observational data linkage epidemiological study of ANCA-associated vasculitis disease outcomes
Recruiting health boards: GGC, Lothian, Grampian, Tayside, Highlands
PI Corri Black
Contact details: matthew.rutherford@glasgow.ac.uk
Vasculitis Outcomes In relation to Care ExperienceS (VOICES)
Health services research project applying mixed methods to identify health care disparities and evolve a bespoke model of care.
Web page: https://www.abdn.ac.uk/iahs/research/epidemiology/vasculitis-1616.php
PI Rosemary Hollick
Contact details : rhollick@abdn.ac.uk
Retinal metrics in ANCA-associated vasculitis
Imaging study using optical coherence tomography (OCT) to assess changes in retinal metrics in patients with ANCA-associated vasculitis compared to healthy controls. Serial scans will explore whether metrics are modifiable over time in response to treatment.
Recruiting health board(s): Lothian
PI: Bean Dhaun
Contact details: fiona.chapman@ed.ac.uk or dpugh2@exseed.ed.ac.uk
Endothelin antagonism in ANCA-associated vasculitis
Cohort study investigating the change in endothelial function (measured by forearm blood flow) in response to endothelin antagonism in patients with vasculitis compared to health.
Recruiting health board(s): Lothian
PI: Bean Dhaun
Contact: bean.dhaun@ed.ac.uk
Monitoring large vessel vasculitis with PET/MR imaging
Longitudinal cohort study investigating the ability of PET/MR to assess and monitor disease activity in large vessel vasculitis.
Recruiting health board(s): Lothian, Borders, Tayside, Lanarkshire, Grampian, GGC, Highland
PI: Bean Dhaun
Contact: dpugh2@exseed.ed.ac.uk